spaz

The term "spaz" is an abbreviation of "spastic," a medical descriptor historically used to refer to muscle spasms and tightness associated with conditions such as cerebral palsy (specifically spastic diplegia). As a colloquialism, it evolved to describe a person who is clumsy, inept, or physically uncoordinated, as well as a verb phrase ("spazzing out") to describe someone acting hyperactive or losing emotional control.

The acceptability of the term is heavily dependent on geography and generational context. In the United Kingdom, Ireland, and Australia, the word has long been considered a severe ableist slur, offensive on par with other hate speech targeting disabilities. Conversely, in the United States, it was frequently used in the late 20th century as mild, often self-deprecating slang for "geeky" or "clumsy" behavior, with many users unaware of its etymological link to cerebral palsy. However, recent global internet culture and advocacy by the disability community have successfully campaigned against its use in American media, arguing that regardless of the speaker's intent, the term mocks the physical movements of disabled people.

Example:
"I tried to catch the glass before it hit the floor, but I'm such a spaz I just knocked over the pitcher too."

Example:
"He started spazzing out when he realized he lost his wallet at the concert."

References:

• Beyoncé is changing a lyric on her Renaissance album that contains an ableist slur... [the word] is often used colloquially in the US with a similar meaning to 'freaking out' or 'going crazy'. (source)